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Mpox outbreak: What are the symptoms and how worried should I be about the new variant in the UK?

A new variant of the disease is mutating more rapidly than expected, scientists say

Alex Croft
Wednesday 30 October 2024 16:19
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EU issues mpox travel warning, urging people to get vaccinated

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A deadly new variant of the Mpox virus has been detected in the UK after months of growing concerns as it spread through countries in Africa, and was detected in Europe and Asia.

The UK Health Security Agency (UKHSA) says the risk to the population “remains low” despite fears surrounding the potentially more dangerous variant of the disease.

It began spreading rapidly in the Democratic Republic of the Congo in September 2023. Since then, scientists have been scrambling to get the disease under control.

The new variant, known as Clade 1b, is mutating rapidly and proving difficult to control, scientists say. It appears to spread more easily, and was therefore declared as a global health emergency by the World Health Organization in Africa on August 15.

The first UK case was detected in London after a holidaymaker travelled back to the UK on an overnight flight on October 21. More than a day later, they developed flu-like symptoms and developed a rash which became worse in the days following. The person was tested on October 27, and is now being treated in the Royal Free Hospital high consequence infectious diseases unit.

Paramedic staff setting up a preventative isolation ward in Pakistan
Paramedic staff setting up a preventative isolation ward in Pakistan (AP)

In 2024, 45,674 suspected cases in Africa have led to 1,014 deaths, according to the Africa Centres for Disease Control and Prevention Epidemic Intelligence weekly report on October 26. This means a case fatality rate (CFR) of 2.22 per cent.

The World Health Organisation declared a global health emergency on August 15, and have called on member states to help fund a $135million battle plan to fight the spread of the virus.

Red Cross officials have been boosting awareness about Mpox in the Don Bosco refugee camp in Doma, Congo
Red Cross officials have been boosting awareness about Mpox in the Don Bosco refugee camp in Doma, Congo (Copyright 2024 The Associated Press. All rights reserved.)

The outbreak “can be controlled and can be stopped”, Director-General Tedros Adhanom Ghebreyesus said, but this will require “approximately $135 million over the next six months for the acute phase of the outbreak”.

What is Mpox and what are the symptoms?

Mpox belongs to the same virus family as smallpox, but produces milder symptoms including fever, chills and body aches. Serious cases can lead to lesions on the face, hand, chest and genitals.

The virus was first identified by scientists in 1958, when it was known as monkeypox after the outbreak of a “pox-like” disease in monkeys. Scientists later changed the name to Mpox for accuracy reasons, with experts suggesting the virus originated from rodents.

The UK government lists the symptoms as: A skin rash with blisters, spots or ulcers that can appear anywhere on your body (including your genitals); fever; headaches, backache, and muscle aches; joint pains; swollen glands; shivering (chills) and exhaustion.

Christophe Chavilinga, 90, suffering from Mpox, waits for treatment at a clinic in Munigi, eastern Congo
Christophe Chavilinga, 90, suffering from Mpox, waits for treatment at a clinic in Munigi, eastern Congo (Copyright 2024 The Associated Press. All rights reserved)

A rash will typically appear one to five days following a fever, often beginning on the face before spreading to other parts of the body.

The vaccine currently available in the UK tackles the Clade 2 variant of Mpox - which spread through the UK in 2022-2023. It is 70 to 85 percent effective if given to people before they receive the vaccine.

How concerned should the UK be?

The new strain of Mpox has spread to multiple countries in Africa including Burundi, Central African Republic, Rwanda, and Uganda.

Sweden reported Europe’s first case of Clade 1b Mpox on August 15 and Germany reported a case on October 23. Thailand reported Asia’s first case on August 22.

Scientists have said it is mutating more rapidly than was expected. Dr. Dimie Ogoina of the Niger Delta University Hospital said experts “don’t understand the outbreak very well”. But UK health authorities say the risk nonetheless “remains low”.

UK authorities still deem the risk to be low
UK authorities still deem the risk to be low (REUTERS)

Professor Susan Hopkins, chief medical adviser at the UKHSA, said: “It is thanks to our surveillance that we have been able to detect this virus. This is the first time we have detected this Clade of mpox in the UK, though other cases have been confirmed abroad.

“The risk to the UK population remains low, and we are working rapidly to trace close contacts and reduce the risk of any potential spread.

“In accordance with established protocols, investigations are underway to learn how the individual acquired the infection and to assess whether there are any further associated cases.”

The focus currently remains on retaining vigilance and controlling the potential thread, rather than imposing travel restrictions.

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