New Covid XEC variant starting to spread in Europe – what we know about signs and symptoms

More contagious virus is sublineage of omicron variant, scientists say

Scientists have warned that a “more contagious” variant of the Covid virus, dubbed XEC, is starting to spread more rapidly across Europe and could soon become the dominant strain.

“At this juncture, the XEC variant appears to be the most likely one to get legs next,” Eric Topol, director of the Scripps Research Translational Institute in La Jolla, said in a post on X on 15 September.

Researchers predicted in August that this variant could take a few weeks to a couple of months to take off and spread more rapidly.

“XEC is definitely taking charge,” Dr Topol said.

XEC, a sublineage of the omicron variant, was first reported in Berlin, Germany, in June and is now spreading “quite rapidly” across Europe, North America and Asia, according to Covid data analyst Mike Honey.

Model of Covid coronavirus (Getty)

Slovenia had high rates of infection with this variant in August as over 10 per cent of Covid case samples from the country contained XEC.

It is a hybrid of previously discovered omicron subvariants – KS.1.1 and KP.3.3 – of the novel coronavirus that causes Covid.

Recombinant variant XEC is continuing to spread, and looks a likely next challenger against the now-dominant DeFLuQE variants (KP.3.1.1.*).

Here are the leading countries reporting XEC. Strong growth in Denmark and Germany (16-17%), also the UK and Netherlands (11-13%).
🧵 pic.twitter.com/rLReeM9wF8

— Mike Honey (@Mike_Honey_) September 15, 2024

KS.1.1 is a type of what’s commonly called a FLiRT variant.

It is characterised by mutations in the building block molecules phenylalanine (F) altered to leucine (L), and arginine (R) to threonine (T) on the spike protein that the virus uses to attach to human cells.

The second omicron subvariant KP.3.3 belongs to the category FLuQE where the amino acid glutamine (Q) is mutated to glutamic acid (E) on the spike protein, making its binding to human cells more effective.

So far, over 500 samples from 27 countries, including Poland, Norway, Luxembourg, Ukraine, Portugal and China, have been found to contain XEC.

Analysts point to strong growth of the variant in Denmark, Germany, the UK, and the Netherlands.

As the novel coronavirus continues to evolve, data suggests XEC is growing steadily each day with an advantage over previously known subvariants.

At this juncture, the XEC variant appears to be the most likely one to get legs next. Its current status nicely tracked by @Mike_Honey_ 's threadhttps://t.co/4AnLa3MXfz

— Eric Topol (@EricTopol) September 15, 2024

Its symptoms are similar to those of previous Covid variants, including fever, sore throat, cough, loss of sense of smell, loss of appetite, and body aches.

But since it is still only a sub-family of the same omicron lineage, experts say keeping up to date with vaccines and booster shots would offer sufficient protection against severe illness and hospitalisation.

The US Centers for Disease Control & Prevention also advises people to practise good hygiene and to take steps for cleaner air.

Researchers have called for monitoring the XEC variant more closely to better understand its symptoms.