Scientists come one step closer to understanding how we could grow new limbs
Tissue regeneration is a complex process - but it could be used in human medicine one day
Your support helps us to tell the story
From reproductive rights to climate change to Big Tech, The Independent is on the ground when the story is developing. Whether it's investigating the financials of Elon Musk's pro-Trump PAC or producing our latest documentary, 'The A Word', which shines a light on the American women fighting for reproductive rights, we know how important it is to parse out the facts from the messaging.
At such a critical moment in US history, we need reporters on the ground. Your donation allows us to keep sending journalists to speak to both sides of the story.
The Independent is trusted by Americans across the entire political spectrum. And unlike many other quality news outlets, we choose not to lock Americans out of our reporting and analysis with paywalls. We believe quality journalism should be available to everyone, paid for by those who can afford it.
Your support makes all the difference.Researchers have come one step closer to unlocking the secrets of tissue regeneration.
A team of scientists from the University of Kentucky built on a 2012 study which found that certain species of mice and rabbits can regenerate damaged skin, rather than just rebuilding it with scar tissue.
Over the course of their study, the Kentucky team found another tissue-regenerating species, the African spiny mouse, which can completely repair holes of up to four millimetres in its ears with new skin.
In the process, they also furthered the scientific understanding of the biological factors which lie behind this unusual trait.
A long-standing question in biology is why humans have such poor regenerative abilities compared to other animals. Injuries can cause us to develop scar tissue, but why can't we grow an entirely new piece of skin, or a new digit or limb?
Previous theories have tended to assume there is a 'magic bullet' for regeneration, like a specific gene, which could be harnessed by scientists for use in medicine.
However, an analysis of the spiny mouse's genes has shown the trait is actually much more complex, and involves the interplay of a number of different genetic factors.
The team also found that the regeneration begins when the mouse forms a blastema, or a mass of cells which eventually grow into organs or body parts.
Thomas Gawriluk, a co-author of a study on the discovery, believes developing a deep understanding of the process is a vital step in using it to help humans.
By figuring out the miniscule molecular and cellular processes that occur during regeneration, we would have a good foundation on which to develop new regenerative medicines.
"First we need to understand how mammalian regeneration works in a natural setting, then comes the potential to create theraputic treatments for humans," he said.
Much more research will need to be done on the topic, but this study is still hugely significant - the spiny mouse is one of only a few mammals which can regenerate tissue, and uncovering the mechanisms behind the process could help make human regeneration a reality.
Join our commenting forum
Join thought-provoking conversations, follow other Independent readers and see their replies
Comments