Magic mushroom compound provides anti-anxiety and antidepressant effects lasting years, study finds

Single dose of psilocybin leads to decreased demoralisation and improved spiritual wellbeing among cancer sufferers, long-term research indicates

A single dose of psilocybin, a compound found in psychedelic mushrooms, can result in “significant improvements” in reducing stress and anxiety in cancer patients for as long as five years after it was administered, a new study suggests.

A research team at New York University‘s Grossman School of Medicine, who were following up a landmark 2016 study into psilocybin, found that in conjunction with psychotherapy, cancer patients experienced improvements in emotional and existential distress.

In the earlier study, the team reported that the use of psilocybin produced “immediate, substantial, and sustained improvements in anxiety and depression and led to decreases in cancer-related demoralisation and hopelessness, improved spiritual wellbeing, and increased quality of life”.

After a follow-up assessment, six-and-a-half months later, psilocybin was associated with “enduring anti-anxiety and antidepressant effects”.

The new study — a long term follow up of the same set of patients — found the positive effects had continued.

“Participants overwhelmingly (71 to 100 per cent) attributed positive life changes to the psilocybin-assisted therapy experience and rated it among the most personally meaningful and spiritually significant experiences of their lives,” the researchers said.

“Adding to evidence dating back as early as the 1950s, our findings strongly suggest that psilocybin therapy is a promising means of improving the emotional, psychological, and spiritual wellbeing of patients with life-threatening cancer,” said the 2016 parent study’s lead investigator, Dr Stephen Ross.

“This approach has the potential to produce a paradigm shift in the psychological and existential care of patients with cancer, especially those with terminal illness.”

The researchers said psilocybin could become a useful tool for enhancing the effectiveness of psychotherapy and ultimately relieving these symptoms.

Although the precise mechanisms are not fully understood, scientists believe the drug can make the brain more flexible and receptive to new ideas and thought patterns. In addition, previous research indicates the drug targets a network of the brain, the default mode network, which becomes activated when we engage in self-reflection and mind wandering, and which helps to create our sense of self and sense of coherent narrative identity.

In patients with anxiety and depression, this network becomes hyperactive and is associated with rumination, worry, and rigid thinking. Psilocybin appears to acutely shift activity in this network and helps people to take a more broadened perspective on their behaviours and lives.

The follow-up study is the longest-spanning exploration of psilocybin’s effects on cancer-related psychiatric distress to date, the authors say.

“These results may shed light on how the positive effects of a single dose of psilocybin persist for so long,” said Gabby Agin-Liebes, lead author of the long-term follow-up study.

“The drug seems to facilitate a deep, meaningful experience that stays with a person and can fundamentally change his or her mindset and outlook,” she said.

The research is published in the Journal of Psychopharmacology.