Jose Mourinho is expected to wring the changes, with Luke Shaw, Michael Carrick and Sergio Romero all in contention to start having not featured in the league this season.
Burton will be without the injured Liam Boyce and cup-tied John Brayford, though midfielders Hope Akpan and Matty Palmer could play a role at Old Trafford this evening.
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What time does it start?
The game kicks off at 8pm on Wednesday 20 September at Old Trafford.
Manchester United vs Everton player ratings
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Where can I watch it?
The game will be broadcast on Sky Sports Main Event. Coverage starts at 7.30pm. Or, follow live updates from our live blog.
It’s a big game for?
Luke Shaw. With the left-back set to feature tonight, this is his big chance to prove his worth to Mourinho as he attempts to work his way back into United’s starting XI. The Englishman flickered in and out of the side towards the end of last season but has once again found himself in exile, with Mourinho increasingly unsure of the player’s quality. Shaw needs to step up to the mark and an impressive performance tonight, despite the calibre of United's opposition, will help him do that.
Shaw has been overlooked by Mourinho this season (Getty Images)
Form?
Manchester United: WWDWW
Burton Albion: WDLDW
Head-to-head?
Burton Albion 0 Manchester United 0, FA Cup, January 2006
Manchester United 5 Burton Albion 0, FA Cup, January 2006
Update from the Emirates: Arsenal 1-0 Doncaster (77 mins)
The hosts are growing frustrated here and have failed to create any clear cut chances in this second-half. Theo Walcott, scorer of the only goal so far, has just gone off for Alex Iwobi.
The visitors snuck in a late goal in injury time through Darikwa but it offered little consolation to what was otherwise a demoralising evening at Stamford Bridge.
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