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The bomb exploded on Sunday in the city of Dera Ismail Khan, police official Javed Khan said.
The city is located near the South Waziristan tribal region where a similar bombing on Saturday killed seven and wounded 30.
Shiite Muslims are observing Ashoura, a feast that commemorates the seventh-century death of Imam Hussein, the Prophet Muhammad's grandson.
The Sunni-Shiite schism over the heir to Muhammad dates back to that time and Sunni extremists often target Shiites mourners during the season.
Pakistan has suspended mobile phone service in major cities during Ashoura to prevent such bombings, which often use cellphones as detonators.
AP
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