Markers for prostate cancer found that could lead to new preventative treatment

‘This takes us a step closer to strategies for preventing the disease’

Shaun Lintern
Health Correspondent
Friday 01 November 2019 14:29 GMT
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High levels of blood hormones leave men facing a 25 per cent higher risk of prostate cancer, says new study
High levels of blood hormones leave men facing a 25 per cent higher risk of prostate cancer, says new study (Getty Images/iStockphoto)

Scientists could be a step closer to reducing the risk of prostate cancer after identifying hormones in men’s blood which are linked to significant increases in the disease, according to a new study.

Presented at the National Cancer Research Institute (NCRI) conference in Glasgow, the study found men with higher levels of free testosterone and a separate growth hormone in their blood were more likely to be diagnosed with the disease.

Factors such as ethnicity, older age and family history of the condition are known to increase the likelihood of developing the cancer.

The study, which looked at 200,000 men, was led by Dr Ruth Travis, an associate professor at the Nuffield Department of Population Health at the University of Oxford.

Dr Travis said: “Prostate cancer is the second most commonly diagnosed cancer in men worldwide after lung cancer and a leading cause of cancer death.

“But there is no evidence-based advice that we can give to men to reduce their risk.

“We were interested in studying the levels of two hormones circulating in the blood because previous research suggests they could be linked with prostate cancer and because these are factors that could potentially be altered in an attempt to reduce prostate cancer risk.”

Researchers looked at 200,452 cancer-free men who were part of the UK Biobank project, and were not taking any hormone therapy.

Blood samples were tested for their levels of testosterone and a growth hormone called insulin-like growth factor-I (IGF-I).

A subset of 9,000 men gave a second blood sample at a later date, to help the researchers account for natural fluctuations in hormone levels.

The men were followed for an average of six to seven years, and within the group there were 5,412 cases of prostate cancer and 296 deaths from the disease.

According to the scientists, those with higher concentrations of the two hormones in their blood were more likely to be diagnosed with prostate cancer.

Analysing the findings as a whole, the scientists say they correspond to a 25 per cent greater risk in men who have the highest levels of IGF-I, compared to those with the lowest.

While those with the highest free testosterone levels face an 18 per cent greater risk of prostate cancer, compared to those with the lowest levels.

Dr Travis said: “This type of study can’t tell us why these factors are linked, but we know that testosterone plays a role in the normal growth and function of the prostate and that IGF-I has a role in stimulating the growth of cells in our bodies.

“What this research does tell us is that these two hormones could be a mechanism that links things like diet, lifestyle and body size with the risk of prostate cancer.

“This takes us a step closer to strategies for preventing the disease.”

Agencies contributed to this report

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