Women given testosterone during gender reassingment process 'start to think more like men'

Research says the brain undergoes structural changes and shrinks in some areas

John von Radowitz
Monday 31 August 2015 18:11 BST
Comments
Exposure to the male hormone reduced the volume of grey matter in two key regions of the brain
Exposure to the male hormone reduced the volume of grey matter in two key regions of the brain (Getty Images)

Your support helps us to tell the story

From reproductive rights to climate change to Big Tech, The Independent is on the ground when the story is developing. Whether it's investigating the financials of Elon Musk's pro-Trump PAC or producing our latest documentary, 'The A Word', which shines a light on the American women fighting for reproductive rights, we know how important it is to parse out the facts from the messaging.

At such a critical moment in US history, we need reporters on the ground. Your donation allows us to keep sending journalists to speak to both sides of the story.

The Independent is trusted by Americans across the entire political spectrum. And unlike many other quality news outlets, we choose not to lock Americans out of our reporting and analysis with paywalls. We believe quality journalism should be available to everyone, paid for by those who can afford it.

Your support makes all the difference.

Women given testosterone while undergoing a sex change start to think more like men after the treatment, research suggests.

Their brains undergo structural changes and shrink in areas that play a key role in language, scientists found.

The discovery reinforces the idea that "men are from Mars and women from Venus" because of the way their brains are wired.

Women are known to have better verbal and multi-tasking skills than men, while men are believed to have a superior spatial ability.

Scientists put 18 female-to-male transsexuals through magnetic resonance imaging (MRI) brain scans before and after four weeks of testosterone treatment.

They found that exposure to the male hormone reduced the volume of grey matter - nerve cells - in two key regions of the brain linked to language processing, Broca's and Wenicke's areas.

Women are known to have better verbal skills than men (Hulton)
Women are known to have better verbal skills than men (Hulton) (Hulton Archive/Getty Images)

At the same time, connections between these two regions became stronger.

Researcher Professor Rupert Lanzenberger, from the University of Vienna, said: "What we see is a real quantitative difference in brain structure after prolonged exposure to testosterone. This would have been impossible to understand without looking at a transsexual population.

"In more general terms, these findings may suggest that the genuine difference between the brains of women and men is substantially attributable to the effects of circulating sex hormones. Moreover, the hormonal influence on human brain structure goes beyond early developmental phases and is still present in adulthood."

The findings were presented at the annual meeting of the European College of Neuropsychopharmacology (ECNP) in Amsterdam, the Netherlands.

Commenting on behalf of the ECNP communications committee, Dr Kamilla Miskowiak, from Copenhagen University Hospital, said: "It is well known that language development differs between girls and boys and that this is related to gender-related differences in brain maturation.

"However, this intriguing neuroimaging study of transsexuals before and after their female-to-male gender reassignment suggests that even adult men and women differ in brain structure within regions involved in language and speech.

"In particular, female-to-male gender reassignment resulted in local brain matter decrease within language processing regions, which may explain why verbal abilities are often stronger in women."Women given testosterone while undergoing a sex change start to think more like men after the treatment, research suggests.

Their brains undergo structural changes and shrink in areas that play a key role in language, scientists found.

The discovery reinforces the idea that "men are from Mars and women from Venus" because of the way their brains are wired.

Women are known to have better verbal and multi-tasking skills than men, while men are believed to have a superior spatial ability.

Scientists put 18 female-to-male transsexuals through magnetic resonance imaging (MRI) brain scans before and after four weeks of testosterone treatment.

They found that exposure to the male hormone reduced the volume of grey matter - nerve cells - in two key regions of the brain linked to language processing, Broca's and Wenicke's areas.

At the same time, connections between these two regions became stronger.

Researcher Professor Rupert Lanzenberger, from the University of Vienna, said: "What we see is a real quantitative difference in brain structure after prolonged exposure to testosterone. This would have been impossible to understand without looking at a transsexual population.

"In more general terms, these findings may suggest that the genuine difference between the brains of women and men is substantially attributable to the effects of circulating sex hormones. Moreover, the hormonal influence on human brain structure goes beyond early developmental phases and is still present in adulthood."

The findings were presented at the annual meeting of the European College of Neuropsychopharmacology (ECNP) in Amsterdam, the Netherlands.

Commenting on behalf of the ECNP communications committee, Dr Kamilla Miskowiak, from Copenhagen University Hospital, said: "It is well known that language development differs between girls and boys and that this is related to gender-related differences in brain maturation.

"However, this intriguing neuroimaging study of transsexuals before and after their female-to-male gender reassignment suggests that even adult men and women differ in brain structure within regions involved in language and speech.

"In particular, female-to-male gender reassignment resulted in local brain matter decrease within language processing regions, which may explain why verbal abilities are often stronger in women."

Press Association

Join our commenting forum

Join thought-provoking conversations, follow other Independent readers and see their replies

Comments

Thank you for registering

Please refresh the page or navigate to another page on the site to be automatically logged inPlease refresh your browser to be logged in